Observation data from 3 groups of mice that received a single dose of the "Painkiller X" tested at prescribed doses and in overdose.

Table 2: Observation data from 3 groups of mice that received a single dose of the "Painkiller X" tested at prescribed doses and in overdose.

ANIMAL ID	Control (n = 5) Eau distillée	Lot 1 (n = 5) *HED*	Lot 2 (n = 5) 2 × HED	Lot 3 (n = 5) 3 × HED
T = ¼ hour	NOR	NOR	NOR	NOR
T = ½ hour	NOR	NOR	NOR	NOR
T = 1 hour	NOR	NOR	NOR	NOR
T = 4 hours	NOR	NOR	NOR	NOR
Day 1	NOR	NOR	NOR	NOR
Day 2	NOR	RN +	RN +	RN ++, PP
Day 3	NOR	PP ++	PP ++	PP+++, CR+++
Day 4	NOR	PP ++	PP ++	PP+++, CR+++
Day 5	NOR	NOR	NOR	PP+++, CR+++
Day 6	NOR	NOR	NOR	CR ++, MO
Day 7	NOR	NOR	NOR	PP +
Day 8	NOR	NOR	NOR	PP +
Day 9	NOR	NOR	NOR	NOR
Day 10	NOR	NOR	NOR	NOR
Day 11	NOR	NOR	NOR	NOR
Day 12	NOR	NOR	NOR	NOR
Day 13	NOR	NOR	NOR	NOR
Day 14	NOR	NOR	NOR	NOR

Abbreviations used: AP: Apathie; TR: Tremor; EX: Excitation; NOR: Nothing to report; CO: Convulsion; RB: Refusal to drink; RN: Refusal to eat; PP: Weight loss; DI: Diarrhoea; MO: Death; CR: Abdominal cramps; SLR: Loose stools