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<article>
	<meta-data>
		<journal-meta>
			<journal-name>International Journal of Immunology and Immunotherapy</journal-name>	
			<journal-shortname>Int J Immunol Immunother</journal-shortname>
			<journal-doi>10.23937/2378-3672</journal-doi>
			<publisher>
				<publisher-name>ClinMed International Library</publisher-name>
				<publisher-location>Wilmington, USA</publisher-location>
				<publisher-doi-prefix>10.23937</publisher-doi-prefix>
			</publisher>
		</journal-meta>
		<article-meta>
			<article-title>The Role of Genetics Mutations in Genes PORCN, TWIST2, HCCS in Goltz Syndrome</article-title>
			<citation_author>Asadi S</citation_author>
			<article-doi>10.23937/2378-3672/1410038</article-doi>
			<article-description>Goltz syndrome (focal skin hypoplasia) is a genetic disorder that primarily affects the skin, skeletal system, eyes and face. People with Goltz syndrome have birth defects. These disorders include very thin skin veins (skin hypoplasia), pink yellow nodules, subcutaneous fat, lack of upper skin layers (aplasia cutis), small clusters of superficial skin vessels (telangiectasia), and veins in dark skin Or bright. Goltz syndrome is caused by mutation genes PORCN, TWIST2, HCCS.</article-description>
		</article-meta>
	</meta-data>
	<body>
		<article-type>REVIEW ARTICLE</article-type>
		<volume>6</volume>
		<issue>1</issue>
		<access-type>OPEN ACCESS</access-type>
		<article-doi>10.23937/2378-3672/1410038</article-doi>
		<article-title>The Role of Genetics Mutations in Genes PORCN, TWIST2, HCCS in Goltz Syndrome</article-title>

		<Author-Group>

			<aut id="aut1">
				<label>Author-1</label>
				<name>Shahin Asadi</name>
				<affiliation>Division of Medical Genetics and Molecular Pathology Research, Molecular Genetics-IRAN-TABRIZ, Iran</affiliation>
			</aut>

			<aut id="aut2">
				<label>Author-2</label>
				<name>Mahsa Jamali</name>
				<affiliation>Division of Medical Genetics and Molecular Pathology Research, Molecular Genetics-IRAN-TABRIZ, Iran</affiliation>
			</aut>

		</Author-Group>
		<author-notes>
			<corres-author>
				<label>Corresponding-Author</label>
				<name>Shahin Asadi</name>
				<affliation>Division of Medical Genetics and Molecular Pathology Research</affliation>
				<address>Molecular Genetics-IRAN-TABRIZ, Iran</address>
			</corres-author>
		</author-notes>
		<history>
			<published-date>
				<day>26</day>
				<month>August</month>
				<year>2019</year>
			</published-date>
		</history>
		<citation>
			<author-names>
				<name>Shahin Asadi</name>,
				<name>Mahsa Jamali</name>
			</author-names>
			<published-year>2019</published-year>
			<article-title>The Role of Genetics Mutations in Genes PORCN, TWIST2, HCCS in Goltz Syndrome</article-title>
			<journal-short-name>Int J Immunol Immunother</journal-short-name>
			<article-doi>10.23937/2378-3672/1410038</article-doi>
		</citation>
		<permissions>
			<copyright>
				<copyright-year>2019</copyright-year>
				<copyright-holder>Asadi S, et al.</copyright-holder>
				<copyright-notes>&#169; This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
				</copyright-notes>
			</copyright>
		</permissions>
		<article-content>
			<Abstract>
				<p>Goltz syndrome (focal skin hypoplasia) is a genetic disorder that primarily affects the skin, skeletal system, eyes and face. People with Goltz syndrome have birth defects. These disorders include very thin skin veins (skin hypoplasia), pink yellow nodules, subcutaneous fat, lack of upper skin layers (aplasia cutis), small clusters of superficial skin vessels (telangiectasia), and veins in dark skin Or bright. Goltz syndrome is caused by mutation genes PORCN, TWIST2, HCCS.</p>
			</Abstract>
			<Keywords>
				<p>Goltz syndrome, PORCN, TWIST2, HCCS genes, Skin and Skeletal disorders</p>
			</Keywords>
			<Generalizations-of-Goltz-Syndrome>
				<p>Goltz syndrome (focal skin hypoplasia) is a genetic disorder that primarily affects the skin, skeletal system, eyes and face. About 90 percent of people with Goltz syndrome are women, and men with symptoms usually have fewer symptoms and symptoms than women. It should be noted that some people with Goltz syndrome also have intellectual disabilities [1] (Figure 1).</p>
			</Generalizations-of-Goltz-Syndrome>
			<Clinical-Symptoms-of-Goltz-Syndrome>
				<p>People with Goltz syndrome have birth defects. These disorders include very thin skin veins (skin hypoplasia), pink yellow nodules, subcutaneous fat, lack of upper skin layers (aplasia cutis), small clusters of superficial skin vessels (telangiectasia), and veins in dark skin Or bright. These skin changes may cause pain, itching, irritation, or skin infections. Papillomas, such as zygomatic mice, are not usually present at birth, but appear as adults grow up in the Goltz syndrome. Papillomas are usually formed around the nose, the lips, the anal holes and the genitals of women with Goltz syndrome. In addition, papillomas may be present in the throat, especially in the esophagus or larynx, and can cause swallowing, respiration or sleep poisoning. The papillomas can be removed if necessary by surgery from the growing regions. People with Goltz syndrome may have small and abnormal nails on the toes. In addition, hair in the scalp of these people can be weak or fragile or not [2] (Figure 2).</p>

				<p>Many people with Goltz syndrome also have hand and foot disorders, including abnormalities such as oligodactyly in fingers and toes, fingers and legs (cindactyly) or ecd rhodactyly. X-rays can show veins of modified bone density called osteopathia striata [3] (Figure 3).</p>

				<p>Eye disorders are common in people with Goltz syndrome and include symptoms such as abnormal (microphalomatic) eyes, unexplained eyes (anophthalmia), sight (strabismus), eyelid splint (ptosis), rapid pupil eye movement (nystagmus) and tear problems are also common. In addition, people with Goltz syndrome may have defects in the sensitive light tissue behind the eye (retina) or nerve that transmits visual information from the eye to the brain (the optic nerve). This abnormal growth of the retina and the optic nerve may cause a chunk of the eye structure called coliboma. It should be noted that some of these abnormalities in the eye do not affect visual acuity, while others may also experience diminished vision or blindness [4] (Figure 4).</p>

				<p>People with Goltz syndrome may have facial features. The injured people often have a small, thin thumb, small ears, nasal holes that are smaller than normal, asymmetry left and right in the face (face asymmetry). These facial features are usually very delicate. In addition, cleft palate and cleft palate may also occur in people with Goltz syndrome [5] (Figure 5).</p>

				<p>About half of the patients with Goltz syndrome have dental disorders, in particular enamel dysfunction. Kidney and gastrointestinal disorders are also common in Goltz syndrome. The kidneys may also fuse with people who have kidney infections that are susceptible to kidney disease, but typically do not cause significant problems in their health. The main gastrointestinal disorder that occurs in people with Goltz syndrome is an ampholecole, which is a hole in the abdominal wall and allows abdominal organs to escape through the umbilical cord. It is worth noting that the symptoms of Goltz syndrome are very different, although almost all people with this syndrome experience skin disorders [6].</p>
			</Clinical-Symptoms-of-Goltz-Syndrome>
			<Etiology-of-Goltz-Syndrome>
				<p>About 90% of the cases of Goltz syndrome are due to the mutation of the PORCN gene, which is based on the X-linked limb X-chromosome arm Xp11.23. This gene contains the instructions for protein synthesis that is responsible for changing other proteins, which is called the WNT protein. The WNT protein is involved in the chemical pathways of body signaling, which regulates the growth of the skin, bones and other structures of the body before birth. About 10% of cases of Goltz syndrome are due to mutations in TWIST2 and HCCS genes. The TWIST2 gene is positioned in the long arm of chromosome number 2 as 2q37.3, and the HCCS gene is based on the x-ray x-chromosome short arm Xp22.2 [7] (Figure 6).</p>
			</Etiology-of-Goltz-Syndrome>
			<Frequency-of-Goltz-Syndrome>
				<p>Goltz syndrome is a rare genetic disorder that is unclear in the world. So far, about 200 to 300 cases of Goltz syndrome have been reported from medical literature throughout the world, and only 10% are men who have been born alive [10].</p>
			</Frequency-of-Goltz-Syndrome>
			<Discussion-and-Conclusion>
				<p>Goltz syndrome (focal skin hypoplasia) is a genetic disorder that primarily affects the skin, skeletal system, eyes and face. People with Goltz syndrome have birth defects. These disorders include very thin skin veins (skin hypoplasia), pink yellow nodules, subcutaneous fat, lack of upper skin layers (aplasia cutis), small clusters of superficial skin vessels (telangiectasia), and veins in dark skin Or bright. Goltz syndrome is caused by mutation genes PORCN, TWIST2, HCCS. There is no definitive treatment for Goltz syndrome and any clinical measures are needed to reduce the suffering of the sufferers</p>
			</Discussion-and-Conclusion>
		</article-content>

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	</body>
</article>			