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<article>
	<meta-data>
		<journal-meta>
			<journal-name>Clinical Medical Image Library</journal-name>	
			<journal-shortname>Clin Med Img Lib</journal-shortname>
			<journal-doi>10.23937/2474-3682</journal-doi>
			<issn>2474-3682</issn>
			<publisher>
				<publisher-name>ClinMed International Library</publisher-name>
				<publisher-location>Wilmington, USA</publisher-location>
				<publisher-doi-prefix>10.23937</publisher-doi-prefix>
			 </publisher>
		</journal-meta>
		<article-meta>
			<article-title>Cobra Head Sign</article-title>
			<citation_author>Phan YC</citation_author>
			<article-doi>10.23937/2474-3682.1510133</article-doi>
			<article-description>A 62-year-old man was referred by his general practitioner to the urology outpatient clinic as his routine blood test showed a raised prostate-specific antigen (PSA) of 10 ug/l. On further questioning, he has minimal lower urinary tract symptoms and there was no symptom to suggest that he had a urinary tract infection recently. Examinations of his abdomen and male genitalia including a digital rectal examination were normal. As recommended by the latest National Institute for Health and Care Excellence (NICE), he underwent a MRI prostate. Not only his MRI scan has picked up a Prostate Imaging Reporting and Data System (PI-RADS) 3 lesion in his anterior part of his prostate, but it has also picked up an incidental left ureterocele which classically is known as a cobra head sign.</article-description>
		</article-meta>
	</meta-data>
	<body>
		<article-type>IMAGE ARTICLE</article-type>
		<volume>5</volume>
		<issue>3</issue>
		<access-type>OPEN ACCESS</access-type>
		<article-doi>10.23937/2474-3682.1510133</article-doi>
		<article-title>Cobra Head Sign</article-title>
		<Author-Group>
			<aut id="aut1">
				<label>Author-1</label>
				<name>Yih Chyn Phan*</name>
				<affiliation>Queen Alexandra Hospital, Portsmouth, UK</affiliation>
			</aut>
			<aut id="aut2">
				<label>Author-2</label>
				<name>Wasim Mahmalji</name>
				<affiliation>The County Hospital, Hereford, UK</affiliation>			
			</aut>
		</Author-Group> 
		<author-notes>
			<corres-author>
				<label>Corresponding-Author</label>
				<name>Phan YC</name>,
				<affliation>Clinical Associate Professor</affliation>
				<address>University of Alabama at Birmingham, 960 Faculty Office Tower, 510 20th St South, Birmingham, Alabama, USA, Tel: 205-996-7258, Fax: 205-975-4701.</address>
			</corres-author>
		</author-notes>
		<history>
			<published-date>
				<day>20</day>
				<month>June</month>
				<year>2019</year>
			</published-date>
		</history>
		<citation>
			<author-names>
				<name>Yih Chyn Phan</name>,
				<name>Wasim Mahmalji</name>
			</author-names>
			<published-year>2019</published-year>
			<article-title>Cobra Head Sign </article-title>
			<journal-short-name>Clin Med Img Lib</journal-short-name>
			<article-doi>10.23937/2474-3682.1510133</article-doi>
		</citation>
		<permissions>
			<copyright>
				<copyright-year>2019</copyright-year>
				<copyright-holder>Phan YC, et al. </copyright-holder>
				<copyright-notes>&#169; This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</copyright-notes>
			</copyright>
		</permissions>
		<article-content>
			<Introduction>
				<p>A ureterocele is a cystic dilatation of distal ureter in the bladder, urethra or both [1]. Commonly, ureterocele is found in the paediatric population due to regular antenatal scanning. The incidence of ureterocelesis reported as 1 in 500 [2], and 4 to 6 times as common in females as males [3]. Although ureteroceles in adults may be symptomatic, they are usually incidental findings.</p>

				<p>We present an interesting magnetic resonance imaging (MRI) image of a left ureterocele of a 62-year-old man who had an MRI prostate to investigate his raised PSA. Classically, this is known as a cobra head sign.</p>
			</Introduction>
			<Keywords>
				<p>Ureterocele, Cobra head sign</p>
			</Keywords>
			<Case>
				<p>A 62-year-old man was referred by his general practitioner to the urology outpatient clinic as his routine blood test showed a raised prostate-specific antigen (PSA) of 10 ug/l. On further questioning, he has minimal lower urinary tract symptoms and there was no symptom to suggest that he had a urinary tract infection recently. Examinations of his abdomen and male genitalia including a digital rectal examination were normal. As recommended by the latest National Institute for Health and Care Excellence (NICE), he underwent a MRI prostate. Not only his MRI scan has picked up a Prostate Imaging Reporting and Data System (PI-RADS) 3 lesion in his anterior part of his prostate, but it has also picked up an incidental left ureterocele which classically is known as a cobra head sign (Figure 1).</p>

				<p>In light of the lesion on his MRI prostate, he underwent a template biopsy of his prostate which fortunately was uneventful. Histologically, none of his 43 prostate biopsy cores picked up any malignancy. His case was subsequently discussed in the local multidisciplinary meeting and the decision from the team was to monitor his PSA in the community.</p>

				<p>With regards to left ureterocele, as he was completely asymptomatic, he did not undergo further investigation or treatment for it.</p>
			</Case>
			<Acknowledgement>
				<p>N/A.</p>
			</Acknowledgement>
			<Conflict-of-Interest>
				<p>N/A.</p>
			</Conflict-of-Interest>
		</article-content>

		<Figures>
			<figure-1>
				<label>Figure 1</label>
				<title><p>Cobra head sign of the left ureterocele.</p></title>
				<graphic-link>https://clinmedjournals.org/articles/cmil/cmil-5-133-001.jpg</graphic-link>
			</figure-1>
		</Figures>	

		<article-references>
			<title>References</title>
			
			<ref id="ref1">
				<label>Reference-1</label>
				<mixed-citation>
				Shokeir AA, Nijman RJ (2002) Ureterocele: An ongoing challenge in infancy and childhood. BJU Int 90: 777-783. https://www.ncbi.nlm.nih.gov/pubmed/12406111
				</mixed-citation>
			</ref>
			
			<ref id="ref2">
				<label>Reference-2</label>
				<mixed-citation>
				Uson AC, Lattimer JK, Melicow MM (1961) Ureteroceles in infants and children: A report based on 44 cases. Pediatrics 27: 971-983. https://www.ncbi.nlm.nih.gov/pubmed/13779382
				</mixed-citation>
			</ref>
			
			<ref id="ref3">
				<label>Reference-3</label>
				<mixed-citation>
				Rickwood AMK, Reiner I, Jones M, Pournaras C (1992) Current management of duplex‐system ureteroceles: experience with 41 patients. Br J Urol 70: 196-200. https://www.ncbi.nlm.nih.gov/pubmed/1393443
				</mixed-citation>
			</ref>
			
		</article-references>
	</body> 
</article>